您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Desglymidodrine
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Desglymidodrine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Desglymidodrine图片
CAS NO:3600-87-1
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Desglymidodrine (ST 1059) 是 Midodrine 的活性代谢物,是一种选择性 α1-肾上腺素受体激动剂。
Cas No.3600-87-1
别名2-氨基-1-(2,5-二甲氧基苯基)乙醇,ST 1059
Canonical SMILESOC(CN)C1=C(OC)C=CC(OC)=C1
分子式C10H15NO3
分子量197.2
溶解度DMF: 1 mg/ml,DMSO: 2 mg/ml,Ethanol: insol,PBS (pH 7.2): insol
储存条件-20буC
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Desglymidodrine is the active metabolite of the prodrug midodrine .1It is formed from midodrine by enzymatic hydrolysis.2Desglymidodrine is an agonist of α1-adrenergic receptors (α1-ARs).1It binds to α1-ARs (Kis = 9.77, 9.55, and 8.51 µM for α1A, α1B, and α1D-ARs, respectively) and increases intraurethral pressure (IUP) and mean arterial pressure (MAP) by 5 and 20 mm Hg, respectively, in anesthetized dogs at doses of 205 and 250 nmol/kg, respectively.

1.Altenbach, R.J., Khilevich, A., Kolasa, T., et al.Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing α1A-adrenoceptor agonistJ. Med. Chem.47(12)3220-3235(2004) 2.McClellan, K.J., Wiseman, L.R., and Wilde, M.I.Midodrine. A review of its therapeutic use in the management of orthostatic hypotensionDrugs Aging12(1)76-86(1998)