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Quinaprilat
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Quinaprilat图片
CAS NO:82768-85-2
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
Quinaprilat 是一种口服活性的非巯基血管紧张素转换酶 (ACE) 抑制剂,是 Quinapril 的活性代谢物。
Cas No.82768-85-2
别名喹那普利
Canonical SMILESOC([C@H](CCC1=CC=CC=C1)N[C@@H](C)C(N2[C@@H](CC3=CC=CC=C3C2)C(O)=O)=O)=O
分子式C23H26N2O5
分子量410.5
溶解度DMSO: Slightly soluble,Methanol: Slightly soluble
储存条件-20буC
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Quinaprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC50= 0.06 nM) and an active metabolite of the ACE inhibitor prodrug quinapril .1,2It inhibits calcium overload and rod to round cell shape change induced by lysophosphatidylcholine (LPC) in isolated rat cardiomyocytes when used at concentrations of 20 and 50 µM.2Quinaprilat (3 µg/kg) reduces the frequency of ventricular fibrillation in a dog model of myocardial ischemia and reperfusion injury.3It also reduces blood pressure and proteinuria in rat models of uranyl nitrate- or 5/6 nephrectomy-induced chronic renal failure when administered at a dose of 0.1 mg/kg.4

1.Perich, R.B., Jackson, B., and Johnston, C.I.Structural constraints of inhibitors for binding at two active sites on somatic angiotensin converting enzymeEur. J. Pharmacol.266(3)201-211(1994) 2.Ma, H., Hashizume, H., Hara, A., et al.Protective effect of quinaprilat, an active metabolite of quinapril, on Ca2+-overload induced by lysophosphatidylcholine in isolated rat cardiomyocytesJpn. J. Pharmacol.79(1)17-24(1999) 3.Fujinaga, H., Wakatsuki, T., Nishikado, A., et al.Electrophysiologic effects of quinaprilat in dogs during acute myocardial ischemia and following reperfusionCoron. Artery Dis.9(10)697-701(1998) 4.Appenroth, D., Beutinger, R., Lupp, A., et al.Effects of a therapy with losartan and quinaprilat on the progression of chronic renal failure in rats after a single dose of uranyl nitrate or 5/6 nephrectomyExp. Toxicol. Pathol.54(5-6)359-366(2003)