SSR 69071 是一种有效的、具有口服活性和选择性的中性粒细胞弹性蛋白酶抑制剂。
| Cas No. | 344930-95-6 |
| 化学名 | 6-methoxy-1,1-dioxo-2-[[4-oxo-9-(2-piperidin-1-ylethoxy)pyrido[1,2-a]pyrimidin-2-yl]oxymethyl]-4-propan-2-yl-1,2-benzothiazol-3-one |
| Canonical SMILES | CC(C)C1=CC(=CC2=C1C(=O)N(S2(=O)=O)COC3=CC(=O)N4C=CC=C(C4=N3)OCCN5CCCCC5)OC |
| 分子式 | C27H32N4O7S |
| 分子量 | 556.63 |
| 溶解度 | DMSO: 25mM,Ethanol: 10mM |
| 储存条件 | Store at 4℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | High affinity, potent inhibitor of human leukocyte elastase (HLE) (IC50= 3.9 nM). Displays species-selectivity (Kivalues are 0.017, 1.70, 3.01, 58 and > 100 nM?for human, mouse, rat, rabbit and porcine elastase respectively). Inhibits HLE-induced lung hemorrhage in mice (ID50= 2.8 mg/kg) and reduces infarct size in anin vivoacute model of coronary ischemia-reperfusion injury. Orally active. |
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