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4-P-PDOT
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
4-P-PDOT图片
CAS NO:134865-74-0
包装与价格:
包装价格(元)
5 mg电议
100 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
4-phenyl-2- propionamidotetralin
产品介绍
4-P-PDOT 是一种选择性和亲和性的褪黑激素受体拮抗剂,可显著抵消褪黑激素介导的抗氧化作用。它对MT2的选择性是 MT1 的 300 倍以上。

产品描述

4-P-PDOT is a potent, selective and affinity Melatonin receptor (MT2) antagonist.

体外活性

In CHO-mt1 cells the amidotetraline 4-P-PDOT (10 mM) has no effect on forskolin-stimulated cyclic AMP levels, either alone, or in the presence of Melatonin. However, in CHO-MT2 cells, 4-P-PDOT is an agonist, producing a concentration-dependent inhibition of forskolin stimulated cyclic AMP, with a pEC50 value of 8.72 and intrinsic activity of 0.86[1].

体内活性

4-P-PDOT (0.5-1.0 mg/kg; intravenous injection; klotho mutant mice) treatment significantly reverses antioxidant effects mediated by Melatonin. And significantly reverses the changes in the levels of these GSH-related parameters. 4-P-PDOT also counteracts Melatonin-mediated attenuation in response to the decreases in phospho-ERK expression, Nrf2 nuclear translocation, Nrf2 DNA-binding activity, and GCL mRNA expression in the hippocampi of klotho mutant mice[2]. 4-P-PDOT treatment significantly reverses the memory function of Melatonin-treated klotho mutant mice.

Cas No.

134865-74-0

分子式

C19H21NO

分子量

279.38

别名

4-phenyl-2- propionamidotetralin

储存和溶解度

DMSO:41.67 mg/mL (149.15 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years