SGC-AAK1-1 是选择性的AAK1(AP2 相关的激酶 1) 抑制剂,IC50=270 nM,Ki=9 nM,也抑制 BMP2K。它用于与 AAK1 相关的 Wnt 途径的研究。
产品描述
SGC-AAK1-1 is a potent and selective inhibitor of AAK1 (AP2 associated kinase 1) (IC50 of 270 nM and a Ki of 9 nM),and is a chemical probe.
体外活性
phosphorylation of AP2M1 (T156)significantly reduced by SGC-AAK1-1 (1.25 μM) and activates WNT-driven BAR activity compared in a dose-dependent manner in HT1080 cells. SGC-AAK1-1 blocks AAK1 kinase activity, resulting in increased β-catenin protein stability and β-catenin-dependent transcription.
Cas No.
2247894-32-0
分子式
C21H25N5O3S
分子量
427.52
储存和溶解度
DMSO:40 mg/mL (93.56 mM),ultrasonic and warming and heat to 60°C
Powder: -20°C for 3 years
In solvent: -80°C for 2 years