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Escitalopram Oxalate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Escitalopram Oxalate图片
CAS NO:219861-08-2
包装与价格:
包装价格(元)
10 mg电议
50 mg电议
100 mg电议

产品名称
依他普仑草酸盐
Cipralex
(S)-(+)Citalopram oxalate
草酸右旋西酞普兰
产品介绍
Escitalopram oxalate 是一种外消旋 Citalopram 的 S-对映体,是一种选择性 5-羟色胺再摄取抑制剂,Ki=0.89 nM,比 R(-)-enantiomer 结合亲和力高 30 倍。它对多巴胺转运体和去甲肾上腺素转运体均有选择性,是一种研究抑郁症的抗抑郁药。

产品描述

Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM.

体外活性

Escitalopram, the S-enantiomer of citalopram, belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). It is used to treat the depression associated with mood disorders. It is also used on occassion in the treatment of body dysmorphic disorder and anxiety. The antidepressant, antiobsessive-compulsive, and antibulimic actions of escitalopram are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin.In vitro studies show that escitalopram is a potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake. Escitalopram has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of such receptors has been hypothesized to be associated with various anticholinergic, sedative, and cardiovascular effects for other psychotropic drugs. The chronic administration of escitalopram is found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Escitalopram does not inhibit monoamine oxidase.

Cas No.

219861-08-2

分子式

C22H23FN2O5

分子量

414.43

别名

依他普仑草酸盐;Cipralex;(S)-(+)Citalopram oxalate;草酸右旋西酞普兰

储存和溶解度

DMSO:41.4 mg/mL (100 mM)
H2O:20.7 mg/mL (50 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years