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Citalopram hydrobromide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Citalopram hydrobromide图片
CAS NO:59729-32-7
包装与价格:
包装价格(元)
10 mg电议
50 mg电议
100 mg电议
200 mg电议

产品名称
Lu 10-171 HBr
氢溴酸西酞普兰
Citalopram HBr
XU-62-320
Nitalapram HBr
Lu 10-171
Bonitrile HBr
产品介绍
Citalopram hydrobromide 是一种选择性 5-羟色胺再摄取抑制剂,可选择性地抑制 CNS 神经元对 5-羟色胺的再摄取,从而增强中枢神经系统中的 5-羟色胺能活性,也具有抗抑郁活性。它抑制兔血小板中 5-HT 的摄取,IC50为 14 nM。

产品描述

Citalopram, a selective serotonin reuptake inhibitor (SSRI), selectively inhibits the CNS neuronal reuptake of serotonin, thereby potentiating serotonergic activity in the central nervous system (CNS). Citalopram Hydrobromide is the orally bioavailable hydrobromide salt of the racemic bicyclic phthalene derivative citalopram with antidepressant activity. This agent has minimal effects on the CNS neuronal reuptake of norepinephrine (NE) and dopamine (DA).

体外活性

Citalopram (Lu 10-171), a new bicyclic phthalane derivative, is an extremely potent inhibitor of neuronal serotonin (5-HT) uptake but has no effect on the uptake of noradrenaline(NA) and dopamine (DA) and no antagonistic activity towards 5-HT, histamine, gamma aminobutyric acid (GABA), acetylcholine, and morphine receptors. It is an extremely specific and potent inhibitor of neuronal 5-HT uptake. Uptake mechanisms for other transmitter amines are not influenced by the drug[1]. The SSRI citalopram has a greater effect on proliferation and a lesser effect on apoptotic activity. It affects cell cycle regulation by increasing proliferative potential and decreasing apoptotic activity in a site specific manner that may be indicative of hyperplasia. Citalopram alters FGF, MSX and TGFB expression in osteoblast cell culture[3].

体内活性

Citalopram is devoid of cardiotoxic effects even when animals are exposed to concentrations far above the therapeutic level. In man citalopram is metabolized to compounds which are also potent 5-HT-uptake inhibitors without effect on noradrenaline(NA) uptake and which are found in lower concentrations than citalopram itself. Citalopram (1-16 mg/kg) stimulates the hind limb flexor reflex in the spinal rat. Citalopram potentiates 5-HT transmission~ possibly by producing very strong uptake inhibition without simultaneously blocking the post-synaptic 5-HT receptors[1].

细胞实验

Cells are cultured in alpha minimum Eagles medium supplemented with 1% penicillin/streptomycin, 10% fetal bovine serum and Amphotericin B. For control data, cells are cultured for 3 or 7 days with standard alpha proliferation media. For SSRI treatments, media is supplemented with citalopram eluted to serially diluted doses between 10?4 mol through 10?10 mol to achieve a dose response curve.(Only for Reference)

Cas No.

59729-32-7

分子式

C20H22BrFN2O

分子量

405.311

别名

Lu 10-171 HBr;氢溴酸西酞普兰;Citalopram HBr;XU-62-320;Nitalapram HBr;Lu 10-171;Bonitrile HBr

储存和溶解度

H2O:4 mg/mL(9.9 mM)
Ethanol:6 mg/mL(14.8 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years