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Ercalcidiol
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Ercalcidiol图片
CAS NO:21343-40-8
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
Ercalcidiol是维生素D2的代谢产物，被视为维生素D营养状况的指标。
Cas No.21343-40-8
别名25-羟基维生素; 25-hydroxy Vitamin D2
化学名(1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-6-hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol
Canonical SMILESCC(C=CC(C)C(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C
分子式C28H44O2
分子量412.66
溶解度DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml,Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
储存条件Store at -20°C,unstable in solution, ready to use.
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ercalcidiol is a metabolite of vitamin D2 and is a VDR-like receptor [1].
Vitamin D is a group of fat-soluble secosteroids and plays an important role in enhancing intestinal absorption of calcium, iron, magnesium, phosphate and zinc. Ercalcidiol (25-hydroxy Vitamin D2) and 25-hydroxyergocalciferol (aka 25-hydroxyvitamin D2 — abbreviated 25(OH) D2) are vitamin D metabolites and Ercalcidiol is converted to 25-hydroxyergocalciferol in liver. Through measuring the level of Ercalcidiol and 25-hydroxyergocalciferol in serum can detect the person's vitamin D status [2] [3].
Using isolated perfused rat kidney model, it was demonstrated that Ercalcidiol not only converted into 24, 25-dihydroxyvitamin D2 but also converted into two other new metabolites-24, 25, 28-trihydroxyvitamin D2 and 24, 25, 26-trihydroxyvitamin D2 [4]. When tested with male weanling rat model, it was demonstrated that either a protein deficiency or a total food restriction during the early postweaning period had no effect on the synthesis and transport of Ercalcidiol and 23, 25-dihydroxyvitamin D in plama [5].
References:
[1].    Jones, G., H.K. Schnoes, and H.F. DeLuca, An in vitro study of vitamin D2 hydroxylases in the chick. J Biol Chem, 1976. 251(1): p. 24-8.
[2].    Newman, M.S., et al., A liquid chromatography/tandem mass spectrometry method for determination of 25-hydroxy vitamin D2 and 25-hydroxy vitamin D3 in dried blood spots: a potential adjunct to diabetes and cardiometabolic risk screening. J Diabetes Sci Technol, 2009. 3(1): p. 156-62.
[3].    Thacher, T.D., et al., Comparison of metabolism of vitamins D2 and D3 in children with nutritional rickets. J Bone Miner Res, 2010. 25(9): p. 1988-95.
[4].   Reddy GS1, Tserng KY. 24, 25, 28-trihydroxyvitamin D2 and 24, 25, 26-trihydroxyvitamin D2: novel metabolites of vitamin D2.Biochemistry. 1990 Jan 30; 29(4):943-9.
[5].   Philbrick DJ, Hollis BW, Draper HH. Effects of protein deficiency on plasma levels of 25-hydroxyvitamin and 24, 25-dihydroxyvitamin D in the rat.
Am J Clin Nutr. 1980 Oct;33(10):2174-6.