您好，欢迎来到化工原料网！ [登录] [免费注册]
化工原料网
发布求购
位置：首页 > 产品库 > IgG light chain variable region [Homo sapiens]/IgM/kappa antibody [Mus musculus]
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
IgG light chain variable region [Homo sapiens]/IgM/kappa antibody [Mus musculus]
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
IgG light chain variable region [Homo sapiens]/IgM/kappa antibody [Mus musculus]图片
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍

IgG light chain region

别名H2N-Thr-Asp-Phe-Thr-Leu-Thr-Ile-OH
Canonical SMILESC[C@@H](O)[C@H](N)C(NC(CC(O)=O)C(NC(CC1=CC=CC=C1)C(N[C@@H]([C@@H](O)C)C(NC(CC(C)C)C(N[C@H](C(N[C@H]([C@@H](C)CC)C(O)=O)=O)[C@@H](O)C)=O)=O)=O)=O)=O
分子式C37H59N7O13
分子量809.9
溶解度≥ 81mg/mL in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IgG has four forms, provides the majority of antibody-based immunity against invading pathogens.[1] The only antibody capable of crossing the placenta to give passive immunity to the fetus. IgM is expressed on the surface of B cells (monomer) and in a secreted form (pentamer) with very high avidity. Eliminates pathogens in the early stages of B cell mediated (humoral) immunity before there is sufficient IgG.[2] The immunoglobulin light chain is the small polypeptide subunit of an antibody ( immunoglobulin). Kappa (NJ) chain, one of the two types of light chain in mammals, is encoded by the immunoglobulin kappa locus (IGK@) on chromosome 2. Only V and J segments are found in Ig light chains.[3]

The approximate length of a light chain protein is from 211 to 217 amino acids.[4]

If the lymph node or similar tissue is reactive, or otherwise benign, it should possess a mixture of kappa positive and lambda positive cells. If, however, one type of light chain is significantly more common than the other, the cells are likely all derived from a small clonal population, which may indicate a malignant condition, such as B-cell lymphoma.[5]

Increased levels of free Ig light chains have also been detected in various inflammatory diseases. Very recent studies have shown that Ig light chains not only activate mast cells but also dorsal root ganglia (Rijnierse, 2009)) and neutrophils (Braber and Thio (2012)), expanding their possible role as mediators in inflammatory disease.

References:
1. Pier GB, Lyczak JB, Wetzler LM (2004). Immunology, Infection, and Immunity. ASM Press. ISBN 1-55581-246-5.
2. Geisberger R, Lamers M, Achatz G (2006). "The riddle of the dual expression of IgM and IgD". Immunology 118 (4): 060526021554006 -- . doi: 10.1111 / j. 1365-2567 . 2006.02386.x. PMC 1782314. PMID 16895553
3. Nemazee D (2006). "Receptor editing in lymphocyte development and central tolerance". Nat Rev Immunol 6 (10): 728-740. doi:10.1038/nri1939.PMID 16998507
4. Janeway CA, Jr. et al. (2001). Immunobiology. (5th ed.). Garland Publishing. (electronic full text via NCBI Bookshelf) ISBN 0-8153-3642-X.
5. Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd.. pp. 283-285.ISBN 1-84110-100-1.