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BMS 193885
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BMS 193885图片
CAS NO:679839-66-8
包装与价格:
包装价格(元)
1 mg电议
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议

产品名称
BMS193885
产品介绍
BMS 193885 是一种选择性和竞争性神经肽 Y(1) 受体拮抗剂,亲和力为 3.3 nM。

产品描述

BMS 193885 is a selective and competitive neuropeptide Y(1) receptor antagonist with affinity of 3.3 nM.

体外活性

BMS 193885 increases the Kd of [(125)I]PeptideYY from 0.35 nM to 0.65 nM without changing the Bmax (0.16 pmol/mg of protein) in SK-N-MC cells that endogenously express the neuropeptide Y(1) receptor[1]. BMS 193885 is a full antagonist with an apparent Kb of 4.5 nM measured by reversal of forskolin-stimulated inhibition of cAMP production by neuropeptide Y[1].

体内活性

BMS 193885 (10 mg/kg; i.p.) reduces one-hour neuropeptide Y-induced food intake in satiated rats, as well as spontaneous overnight food consumption. Chronic administration of BMS 193885 (10 mg/kg) i.p. for 44 days significantly reduces food intake and the rate of body weight gain compared to vehicle treated control without developing tolerance or affecting water intake[1].

Cas No.

679839-66-8

分子式

C36H48N4O9

分子量

680.79

别名

BMS193885

储存和溶解度

H2O:<13.62mg/ml
DMSO:<68.08mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years