您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Boc-NH-PEG4-CH2COOH
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Boc-NH-PEG4-CH2COOH
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Boc-NH-PEG4-CH2COOH图片
CAS NO:876345-13-0
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议

产品介绍
Boc-NH-PEG4-CH2COOH 是一种可降解的 ADC linker,用于合成可降解的抗体偶联药物 (ADC) 的 ADC linker。Boc-NH-PEG4-CH2COOH 也是一种基于 PEG 的 PROTAC linker,可用于 PROTAC 的合成。
Cas No.876345-13-0
别名N-叔丁氧羰基-四聚乙二醇-乙酸
分子式C15H29NO8
分子量351.39
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Boc-NH-PEG4-CH2COOH is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC). Boc-NH-PEG4-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Maggie Lu, et al. Linker-drug and antibody-drug conjugate (adc) employing the same. EP3335734A1.