您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > 20-(tert-Butoxy)-20-oxoicosanoic acid
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
20-(tert-Butoxy)-20-oxoicosanoic acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
20-(tert-Butoxy)-20-oxoicosanoic acid图片
CAS NO:683239-16-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
20-(tert-Butoxy)-20-oxoicosanoic acid 是不可降解 (non-cleavable) 的 ADC linker,用于合成抗体偶联药物 (ADCs)。20-(tert-Butoxy)-20-oxoicosanoic acid 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker,可用于合成 PROTAC。
Cas No.683239-16-9
别名二十烷二酸单叔丁酯
分子式C24H46O4
分子量398.62
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

20-(tert-Butoxy)-20-oxoicosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 20-(tert-Butoxy)-20-oxoicosanoic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.