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N3-PEG3-CH2CH2COOH
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
N3-PEG3-CH2CH2COOH图片
CAS NO:1056024-94-2
包装与价格:
包装价格(元)
50mg电议
100mg电议

产品介绍
N3-PEG3-CH2CH2COOH 是基于PEG 的 PROTAC linker,可用于合成BI-3663 、BI-4216 和 BI-0319。N3-PEG3-CH2CH2COOH 同时也是一种不可降解 (non-cleavable) 的含 3 个单元 PEG 的 ADC linker,可用于合成抗体偶联药物 (ADC)。
Cas No.1056024-94-2
别名叠氮-三乙二醇-丙酸
分子式C9H17N3O5
分子量247.25
溶解度DMSO : 100 mg/mL (404.45 mM; Need ultrasonic)
储存条件-20°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

N3-PEG3-CH2CH2COOH a PEG-based PROTAC linker can be used in the synthesis of BI-3663 , BI-4216 and BI-0319. Azido-PEG3-acid is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[1]. Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520.