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Boc-piperazine-benzoic acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Boc-piperazine-benzoic acid图片
CAS NO:162046-66-4
包装与价格:
包装价格(元)
500mg电议
1 g电议

产品介绍
Boc-piperazine-benzoic acid 是一种 PROTAC linker,可用来合成 PROTAC,例如雄激素受体 (AR) 降解剂 ARD-2128 。
Cas No.162046-66-4
别名4-(4-羧基苯基)哌嗪-1-羧酸叔丁酯
分子式C16H22N2O4
分子量306.36
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Boc-piperazine-benzoic acid is a PROTAC linker and can be used in the synthesis of PROTACs, such as PROTAC androgen receptor (AR) degrader ARD-2128 [1].

ARD-2128 is a highly potent, orally bioavailable PROTAC androgen receptor (AR) degrader. ARD-2128 effectively reduces AR protein, suppresses AR-regulated genes in tumor tissues, and inhibits growth of tumor without signs of toxicity. ARD-2128 has the potential for the research of the prostate cancer[1].

[1]. Han X, et al. Strategies toward Discovery of Potent and Orally Bioavailable Proteolysis Targeting Chimera Degraders of Androgen Receptor for the Treatment of Prostate Cancer. J Med Chem. 2021;64(17):12831-12854.