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N-Boc-cis-4-hydroxy-D-proline methyl ester
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
N-Boc-cis-4-hydroxy-D-proline methyl ester图片
CAS NO:114676-69-6
包装:1 g
市场价:315元

产品介绍
N-Boc-cis-4-hydroxy-D-proline methyl ester 是不可降解 (non-cleavable) 的 ADC linker，用于合成抗体偶联药物 (ADCs)。N-Boc-cis-4-hydroxy-D-proline methyl ester 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。
Cas No.114676-69-6
别名顺式-1-BOC-4-羟基-D-脯氨酸甲酯
分子式C11H19NO5
分子量245.27
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

N-Boc-cis-4-hydroxy-D-proline methyl ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-D-proline methyl ester is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.