Berbamine是从中药伏牛中提取的一种天然产物，是钙通道阻滞剂，具有抗肿瘤、免疫调节和心血管作用。

1. Berbamine has high binding affinity toward the (GGA);G-quadruplex. 2. Berbamine and its derivatives are promising agents to suppress liver cancer growth by targeting CAMKII. 3. Berbamine may be the first ATP-competitive inhibitor of CaMKII γ, could be as a new type of molecular targeted agent through inhibition of the CaMKII γ activity for treatment of leukemia. 4. Berbamine can enhance the antitumor activity of gemcitabine by inhibiting cell growth and inducing apoptosis, possibly through the regulation of the expression of apoptosis-related proteins and the activation of TGF-β/Smad signaling pathway. 5. Berbamine confers cardioprotection against I/R injury by attenuating [Ca(2+)inf(i) overloading and preventing calpain activation through the activation of the PI3K-Akt-GSK3β pathway and, subsequently, opening of the mitoK(ATP) channel.

478-61-5

C37H40N2O6

608.735

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble
DMSO:91 mg/mL(149.5 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years