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PROTAC KRAS G12C degrader-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PROTAC KRAS G12C degrader-1图片
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
PROTAC KRAS G12C degrader-1 是一种基于 Cereblon 的 KRASG12C 降解剂,对 CRBN 的 IC50 为 414 nM。PROTAC KRAS G12C degrader-1 诱导 CRBN/KRASG12C 二聚化并降解报告细胞中的 GFP-KRASG12C。
分子式C50H54ClFN8O6
分子量917.47
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PROTAC KRAS G12C degrader-1 is a Cereblon-based KRASG12C degrader, with an IC50 of 414 nM for CRBN. PROTAC KRAS G12C degrader-1 induces CRBN/ KRASG12C dimerization and degrades GFP- KRASG12C in reporter cells[1].

PROTAC KRAS G12C degrader-1 (Compound 12) engages CRBN in cells, bound KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in reporter cells in a CRBN-dependent manner[1].

[1]. Zeng M, et, al. Exploring Targeted Degradation Strategy for Oncogenic KRAS G12C. Cell Chem Biol. 2020 Jan 16;27(1):19-31.e6.