2',5'-DideoxyadeNOSine 是一种非竞争性腺苷酸环化酶抑制剂，通过结合 P 位点，IC50为 3 μM。它是核苷类似物，在心脏中发挥强大的抗肾上腺素作用。

2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site (IC50: 3 μM).

2',5'-Dideoxyadenosine (20-150 mM), like adenosine, dependently and reversibly inhibits the positive inotropic and chronotropic effect of beta-adrenergic stimulation with isoproterenol (8-54 pmol) up to 70% and 50%, respectively [2]. 2',5'-Dideoxyadenosine (10 μM, 30 min) reduces cAMP production and blocks the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh). 2',5'-Dideoxyadenosine (10 μM, 30 min) blocks CCh-induced increase of phosphorylation of Akt and attenuates CCh-induced phosphorylation of Ser2448 [3].

2',5'-Dideoxyadenosine (0.1 mg/kg; i.p.; 15 min pre-treated) fully inhibits the natriuretic, diuretic and K+ and Cl- sparing effect of Fr?EtOAc in rats [4].

Primary hippocampal neurons. Concentration: 10 μM. Incubation Time: 30 min [3]

Male Wistar rats (3-4 months old).Dosage: 0.1 mg/kg.Administration: i.p.; 15 min pre-treated [3]

6698-26-6

C10H13N5O2

235.24

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years