ST034307 是一种选择性Adenylyl cyclase 1抑制剂，IC50值为 2.3 μM。

ST034307 is an effective and selective inhibitor of adenylyl cyclase 1 (IC50: 2.3 μM).

ST034307 obviously inhibits the forskolin- or isoproterenol-stimulated AC1 activity in HEK cells stably expressing AC1. ST034307 significantly inhibits the Ca2+/calmodulin-stimulated cAMP accumulation in the hippocampal homogenates. ST034307 dose-dependently inhibits both the development and the maintenance of the MOR-mediated sensitization of AC1. ST034307 reveals selective inhibition of AC1 and potentiates AC8 activity to a nonsignificant small extent. ST034307 potentiates phorbol 12-myristate 13-acetate (PMA)-stimulated cAMP production by AC2. ST034307 has no significant effects on wild-type HEK cells [1].

ST034307 shows an estimated median effective dose (E50) value for analgesia of 0.28 μg in the mouse pain model. ST034307 (0.25 μg) induces an obvious relief of CFA-induced inflammatory pain in mice [1].

133406-29-8

C10H4Cl4O2

297.95

DMSO:50 mg/mL (167.81 mM),Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years