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EUK-134
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
EUK-134图片
CAS NO:81065-76-1
包装与价格:
包装价格(元)
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
EUK 134
乙基双亚氨基甲基愈创木酚锰氯化物
产品介绍
EUK 134 是合成的超氧化物歧化酶和过氧化氢酶模拟物,可保护大鼠肾脏免受缺血再灌注引起的损伤。它作用于 H9C2 细胞,降低NF-Κb表达、MDA 水平和蛋白质羰基化。它是具有过氧化氢酶活性的超氧化物歧化酶 (SOD) 模拟物 (SODm)。它是保护有丝分裂的抗氧化剂。

产品描述

EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.

体外活性

EUK 134 shows potent catalase and SOD activities, and protects human fibroblasts against cytotoxicity by glucose and glucose oxidase. [1] EUK 134 (20 μM) prevents Aβ-induced microglial proliferation in vitro. [2] In SK-N-MC cells, EUK134 protects neuronal cells against H(2)O(2) toxicity by attenuating oxidative stress through inhibition of MAPK pathway, and also results in decreased expression of pro-apoptotic genes p53 and Bax as well as enhanced expression of anti-apoptotic Bcl-2 gene. [3] EUK 134 significantly inhibits amyloid formation at two molar ratios of 1:1 and 5:1 (drugs to protein). [4]

体内活性

EUK 134 (2.5 mg/kg), in a middle cerebral artery occlusion model, significantly reduces brain infarct size, and apparently prevents further infarct growth. [1] EUK-134 prevents oxidative stress and attenuates rat brain damage induced by systemic administration of systemic kainic acid (KA). [5]

Cas No.

81065-76-1

分子式

C18H18ClMnN2O4

分子量

416.74

别名

EUK 134;乙基双亚氨基甲基愈创木酚锰氯化物

储存和溶解度

DMSO:77 mg/mL (184.8 mM)
H2O:11 mg/mL (26.4 mM)
Ethanol:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years