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PSB-603
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PSB-603图片
CAS NO:1092351-10-4
包装与价格:
包装价格(元)
50 mg电议
100 mg电议

产品名称
PSB 603
产品介绍
PSB-603 是 AdeNOSine A2B receptor (Ki = 0.553 nM) 的选择性拮抗剂,具有抗炎作用。

产品描述

PSB-603 is a selective antagonist of Adenosine A2B receptor(Ki = 0.553 nM) with anti-inflammatory effects.

体外活性

In peripheral T cells, PSB-603 (100 nM) inhibits NECA-stimulated IL-6 release about 3-fold[2]. PSB-603 (10 μM) shows no affinity for the human and rat A1 and A2A and human A3 receptors[4].

体内活性

PSB-603 (5 mg/kg; i.p.) significantly reduces inflammation in local and systemic mice models of inflammation. In the inflamed paw, PSB-603 significantly decreases the levels of the inflammatory cytokines including IL-6, TNF-α and of ROS. PSB-603 reduces inflammation of the peritoneum by decreasing the infiltration of leukocytes[3].

Cas No.

1092351-10-4

分子式

C24H25ClN6O4S

分子量

529.01

别名

PSB 603

储存和溶解度

DMSO:23.9mg/mL (45.1mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years