2-Chloro-N6-cyclopentyladeNOSine 是一种有效的选择性腺苷 A1 受体激动剂。

2-Chloro-N6-cyclopentyladenosine is a potent and selective agonist of adenosine A1 receptor

2-Chloro-N6-cyclopentyladenosine suppressed the mRNA and protein expressions of CnAβ and exerted antihypertrophic effects to a greater degree than CsA. The inhibition of 2-Chloro-N6-cyclopentyladenosine on cardiomyocyte hypertrophy was counteracted by the A1 receptor antagonist DPCPX[1].

2-Chloro-N6-cyclopentyladenosine (CCPA) was synthesized as a potential high affinity ligand for A1 adenosine receptors. Binding of [3H]PIA to A1 receptors of rat brain membranes was inhibited by CCPA with a Ki-value of 0.4 nM, compared to a Ki-value of 0.8 nM for the parent compound N6-cyclopentyladenosine (CPA)[2].

37739-05-2

C15H20ClN5O4

369.81

2-CHLORO-N-CYCLOPENTYLADENOSINE;2-氯-N6-环戊基腺苷;CCPA;2-chloro-N(6)cyclopentyladenosine

DMSO:55 mg/ml (148.73 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years