AF-353 是一种选择性、可口服的P2X3/P2X2/3 受体拮抗剂，抑制人和大鼠 P2X3 的pIC50值为 8.0，抑制人 P2X2/3 的pIC50值为 7.3。

AF-353, an effective and orally bioavailable antagonist of the P2X3/P2X2/3 receptor, inhibits human and rat P2X3 (pIC50= 8.0).

865305-30-2

C14H17IN4O2

400.22

Ro-4

DMSO:32 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years