Rilematovir 是一种融合蛋白抑制剂,具有抗病毒活性和低细胞毒性。 Rilematovir 可用于呼吸道合胞病毒治疗的研究。
产品描述
Rilematovir is an inhibitor of fusion protein with antiviral activity and low cytotoxicity. Rilematovir can be used in studies about respiratory syncytial virus treatment.
体外活性
Rilematovir is highly active against a number of RSV strains from both A and B subtypes, especially the A2 strain. The EC50 of HeLa cells is 460 pM[1].
体内活性
Rilematovir efficiently suppresses established acute lower respiratory tract infection in the animals after oral treatment of neonatal lambs with Rilematovir, or with an equally active close analog[1].
Cas No.
1383450-81-4
分子式
C21H20ClF3N4O3S
分子量
500.92
别名
JNJ-53718678;JNJ-678
储存和溶解度
DMSO:58.5mg/mL (116.8mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years