包装 | 价格(元) |
500 µg | 电议 |
1mg | 电议 |
Canonical SMILES | O=C(N1CCN(C2=C(C(N(C3C(NC(CC3)=O)=O)C4=O)=O)C4=CC=C2)CC1)C(CC5)CCN5C6=CC=C(NC(C7=CN=C(OC8=CC=CC=C8)N=C7)=O)C=C6 |
分子式 | C40H38N8O7 |
分子量 | 742.8 |
溶解度 | DMSO: 10 mg/ml |
储存条件 | -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | PROTAC(H-PGDS)-7 is a proteolysis-targeting chimera (PROTAC) comprised of the hematopoietic prostaglandin D synthase (H-PGDS) inhibitor TFC-007 and the cereblon inhibitor pomalidomide .1It induces degradation of H-PGDS in KU812 cells with a 50% degradation concentration (DC50) value of 17.3 pM, as well as decreases the production of prostaglandin D2(PGD2) in the same cells. 1.Yokoo, H., Shibata, N., Endo, A., et al.Discovery of a highly potent and selective degrader targeting hematopoietic prostaglandin D synthase via in silico designJ. Med. Chem.64(21)15868-15882(2021) |