您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Abnormal Cannabidiol-d3
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Abnormal Cannabidiol-d3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Abnormal Cannabidiol-d3图片
包装与价格:
包装价格(元)
100 µg电议
500 µg电议
1mg电议
5mg电议

产品介绍
Internal standard for the quantification of abnormal cannabidiol
Canonical SMILESCC1=C[C@@H](C2=C(CCCCC([2H])([2H])[2H])C=C(O)C=C2O)[C@H](C(C)=C)CC1
分子式C21H27D3O2
分子量317.5
溶解度DMF: 50 mg/ml,DMSO: 60 mg/ml,DMSO:PBS (pH 7.2)(1:3): 0.25 mg/ml,Ethanol: 35 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Abnormal cannabidiol-d3contains three deuterium atoms at the terminal methyl position. It is intended for use as an internal standard for the quantification of abnormal cannabidiol by GC- or LC-mass spectrometry. Traditionally, the activity of cannabinoid (CB) agonists was thought to be transduced by a pair of G protein-coupled receptors, CB1and CB2.1Abnormal cannabidiol-d3is a synthetic regioisomer of cannabidiol that fails to elicit either CB1or CB2responsiveness and is without psychotropic activity. Abnormal cannabidiol-d3induces endothelium-dependent vasodilationviaa CB1/CB2/nitric oxide-independent mechanism.2At a dose of 20 µg/g in rats, abnormal cannabidiol-d3showed hypotensive activity that could not be antagonized by cannabidiol or SR141716A. Abnormal cannabidiol-d3is therefore believed to activate a third type of CB receptor, provisionally called the non-CB1/CB2endocannabinoid receptor. Abnormal cannabidiol-d3also actsviathese receptors to regulate the migratory activity of murine BV-2 microglial cells, with an EC50value of 600 nM.3

1.Felder, C.C., Joyce, K.E., Briley, E.M., et al.Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptorsMol. Pharmacol.48(3)443-450(1995) 2.JÁrai, Z., Wagner, J.A., Varga, K., et al.Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptorsProc. Natl. Acad. Sci. U.S.A.96(24)14136-14141(1999) 3.Walter, L., Franklin, A., Witting, A., et al.Nonpsychotropic cannabinoid receptors regulate microglial cell migrationJournal of Neuroscience23(4)1398-1405(2003)