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Carazolol-d7
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Carazolol-d7图片
CAS NO:1173021-02-7
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
An internal standard for the quantification of carazolol
Cas No.1173021-02-7
别名咔唑-D7,(±)-Carazolol-d7; DL-Carazolol-d7; Suacron-d7
Canonical SMILESOC(CNC(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])COC1=C(C(C=CC=C2)=C2N3)C3=CC=C1
分子式C18H15D7N2O2
分子量305.4
溶解度DMSO: slightly,Methanol: very slightly
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Carazolol-d7 is intended for use as an internal standard for the quantification of carazolol by GC- or LC-MS. Carazolol is a β-adrenergic receptor (β-AR) ligand (Kds = 0.2, 0.03, and 4.47 nM for the human β1-, β2-, and β3-ARs, respectively).1It reduces epinephrine-induced increases in mean arterial blood pressure and heart rate in conscious pigs when administered at a dose of 10 µg/kg.2Carazolol has been found in wastewater effluent.3Formulations containing carazolol have been used to reduce stress in livestock during transport.

1.Baker, J.G.The selectivity of β-adrenoceptor agonists at human β1-, β2- and β3-adrenoceptorsBr. J. Pharmacol.160(5)1048-1061(2010) 2.Gregory, N.G., and Wilkins, L.J.The effect of carazolol on the cardiovascular responses to adrenaline in stress sensitive pigsVet. Res. Commun.5(3)277-283(1982) 3.Ternes, T.A.Occurrence of drugs in German sewage treatment plants and riversWater Res.32(11)3245-3260(1998)