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Erdosteine-13C4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Erdosteine-13C4图片
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Erdosteine-13C4 (RV 144-13C4) 是一种13C 标记的 Erdosteine。Erdosteine 抑制脂多糖 (LPS) 诱导的 NF-κB 激活。Erdosteine 具有粘液调节,抗菌,抗炎和抗氧化作用。
别名RV 144-13C4
分子式C413C4H11NO4S2
分子量253.28
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Erdosteine-13C4 (RV 144-13C4) is a 13C-labeled Erdosteine. Erdosteine inhibits lipopolysaccharide (LPS)-induced NF-κB activation[1][2]. Erdosteine has muco-modulatory, anti-bacterial, anti-inflammatory and anti-oxidant effects[3].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Park JS, et al. Anti-inflammatory Effect of Erdosteine in Lipopolysaccharide-Stimulated RAW 264.7 Cells. Inflammation. 2016 Aug;39(4):1573-81.;Oktar S, et al. Beneficial effect of erdosteine on methotrexate-induced testicular toxicity in mice. Toxicol Ind Health. 2010 Aug;26(7):433-8.;Recipharm’s proprietary molecule Erdosteine recognised as COPD treatment