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RG14620
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
RG14620图片
CAS NO:136831-49-7
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
RG 14620
Tyrphostin RG14620
产品介绍
RG14620是一种EGFR抑制剂,IC50值为3 μM。

产品描述

RG14620 is an epidermal growth factor receptor (EGFR) inhibitor.

体外活性

RG-14620 inhibits colony formation and DNA synthesis by HER 14 cells, which are stimulated by 50 ng/mL EGF, in a dose-dependent manner. The IC50s for RG-14620 are 3 μM for HER 14 colony formation and 1 pM for HER 14 DNA synthesis[1]. RG-14620 also suppresses colony formation and DNA synthesis by EGF-stimulated MH-85 cells in a dose-dependent manner. The IC50s for RG-14620 on MH-85 cells are 4 μM for colony formation and 1.25 μM for DNA synthesis[1].

体内活性

RG-14620, at a dose of 200 μg/mouse/day inhibits MH-85 tumor growth in nude mice. Mice show less cachexia and hypercalcemia, eat more food, and are more active than untreated MH-85 tumor-bearing animals[1].

细胞实验

RG14620 is dissolved in 100% DMSO and diluted with the culture medium before addition to the cells. MH-85 and HER 14 cells are cultured in the medium in the presence or absence of increasing concentrations of RG-13022 or RG-14620 for 10 days. At the end of culture, the cells are fixed with 4% (v/v) formaldehyde in calcium-magnesium-free phosphate-buffered saline for 15 min at room temperature and stained with hematoxylin. Numbers of colonies including more than 20 cells in each well are counted under the microscope[1].

Cas No.

136831-49-7

分子式

C14H8Cl2N2

分子量

275.13

别名

RG 14620;Tyrphostin RG14620

储存和溶解度

DMSO:26 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years