Terfenadine 是一种HERG开放通道抑制剂，IC50为 204 nM。它也是一种 H1 组胺受体拮抗剂，通过调节Ca2+稳态在黑素瘤细胞中起到有效的细胞凋亡诱导作用。 Terfenadine 诱导 ROS 依赖性细胞凋亡，同时激活Caspase-4，-2，-9。

Terfenadine is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic and non-sedative effects.

50679-08-8

C32H41NO2

471.685

(±)-Terfenadine;特非那定;MDL-991

DMSO:47.2 mg/mL(100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years