Endoxifen Z-isomer是Tamoxifen最重要的代谢产物,在表达ERα的乳腺癌细胞中发挥抗雌激素作用。它以浓度依赖的方式抑制HERG, IC50值为1.6μM。

Endoxifen (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase activity.

112093-28-4

C25H27NO2

373.496

Endoxifen Z-isomer;Z-因多昔芬;4-[(1E)-1-{4-[2-(甲基氨基)乙氧基]苯基}-2-苯基-1-丁烯-1-基]苯酚

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years