| CAS NO: | 530151-56-5 |
| 包装 | 价格(元) |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 530151-56-5 |
| 别名 | 叠氮-三聚乙二醇-丙炔基 |
| 分子式 | C6H12BrN3O2 |
| 分子量 | 238.08 |
| 溶解度 | DMSO : 100 mg/mL (420.03 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C, stored under nitrogen |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Bromo-PEG2-C2-azide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bromo-PEG2-C2-azide is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. [1]. Yong Zu Kim, et al. Antibody-drug conjugates comprising branched linkers and methods related thereto. WO2017089895A1. |
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