SYP-5 是新型HIF-1抑制剂，阻碍肿瘤细胞侵袭和血管生成。

SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.

A novel HIF-1 inhibitor SYP-5 was first observed by the luciferase reporter assay.?Western blots results showed SYP-5 inhibited hypoxia-induced upregulation of HIF-1.?Moreover, the proteins of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP)-2 that are targets of HIF-1, were down-regulated by SYP-5.?Furthermore, in the tube formation assay, SYP-5 suppressed angiogenesis induced by hypoxia and VEGF in vitro.?Additionally, using Transwell and RTCA assays, we found that SYP-5 also retarded the Hep3B and Bcap37 cells migration and invasion induced by hypoxia and FBS.?Detected the upstream pathways related to HIF-1 and found both PI3K/AKT and MAPK/ERK were involved in the SYP-5 mediated invasive inhibition of Bcap37 cells.?SYP-5 inhibits tumor cell migration and invasion, as well as tumor angiogenesis, which are mediated by suppressing PI3K/AKT- and MAPK/ERK-dependent HIF-1 pathway.?It suggests that SYP-5 might be a potential HIF-1 inhibitor as an anticancer agent.

1384268-04-5

C18H16O3S

312.38

DMSO:33.33 mg/mL (106.70 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years