GN44028 是缺氧诱导因子(HIF)-1的有效抑制剂，其IC50=14 nM。它可以抑制低氧诱导的HIF-1α 的转录特性，但不抑制HIF-1α mRNA 的表达，HIF-1α 蛋白的累积或HIF-1α/HIF-1β 的异缘二聚化。

GN44028 is a hypoxia-inducible factor inhibitor of (HIF)-1 (IC50: 14 nM). GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity. However, It can not be suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization.

1421448-26-1

C18H15N3O2

305.33

N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine

DMSO:44 mg/mL (144.11 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years