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Src Inhibitor 1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Src Inhibitor 1图片
CAS NO:179248-59-0
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Src Kinase Inhibitor 1
Src-l1
产品介绍
Src Inhibitor 1 是一种选择性的、高效的、ATP-竞争性的双位点Src酪氨酸激酶抑制剂,能够抑制 Src (IC50:44 nM) 和 Lck (IC50:88 nM)。

产品描述

Src Inhibitor 1 is a potent and selective dual site Src tyrosine kinase inhibitor.

体外活性

Src-I1 is competitive with both ATP and peptide binding sites of the kinase. The IC50 values are 44 and 88 nM for Src and Lck, respectively[1]. Src-I1, is found to be a potent inhibitor of Src (IC50=0.18 μM), but also inhibited other Src family members, such as Lck, Csk and Yes with similar potency to Src, and RIP2 (IC50=0.026 μM) with even greater potency. In addition, it inhibited CHK2 with similar potency to Src, and Aurora B with slightly lower potency[2].

激酶实验

Assays (25.5 μL volume) are carried out robotically at room temperature (21°C) and are linear with respect to time and enzyme concentration under the conditions used. Assays are performed for 30 min using Multidrop Micro reagent dispensers in a 96-well format. The concentration of magnesium acetate in the assays is 10 mM and [γ-33P]ATP (800 c.p.m./pmol) is used at 5, 20 or 50 μM as indicated, in order to be at or below the Kmfor ATP for each enzyme.The assays are initiated with MgATP, stopped by the addition of 5 μL of 0.5 M orthophosphoric acid and spotted on to P81 filter plates using a unifilter harvester. The IC50 values of inhibitors are determined after carrying out assays at ten different concentrations of each compound[2].

Cas No.

179248-59-0

分子式

C22H19N3O3

分子量

373.412

别名

Src Kinase Inhibitor 1;Src-l1

储存和溶解度

DMSO:6.2 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years