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JQKD82
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JQKD82图片
CAS NO:2410512-38-6
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议

产品介绍
JQKD82 是 KDM5 的选择性抑制剂,可增加 H3K4me3。 JQKD82可用于治疗多发性骨髓瘤的研究。

产品描述

JQKD82 is a selective inhibitor of KDM5 and increases H3K4me3. JQKD82 can be used in studies about the treatment of multiple myeloma.

体外活性

In MM.1S and MOLP-8 cells, JQKD82 (1 μM) induces G1 cell cycle arrest. JQKD82 (0.3 μM) increases global H3K4me3 levels in MM.1S cells. JQKD82 (0.1-10 μM) inhibits the growth of MM.1S cells in a dose- and time-dependent manner (IC50 = 0.42 μM)[1].

体内活性

In female NSG mice bearing MOLP-8 TurboGFP-Luc cells, JQKD82 (50 and 75 mg/kg; i.p.) significantly reduces tumor burden. JQKD82 increases the level of H3K4me3 and significantly reduces MYC immuno-staining in vivo[1].

Cas No.

2410512-38-6

分子式

C27H40N4O5

分子量

500.63

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years