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T-3775440 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
T-3775440 hydrochloride图片
CAS NO:1422535-52-1
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
T-3775440 hydrochloride 是一种不可逆的赖氨酸特异性组蛋白去甲基化酶 (LSD1) 抑制剂,IC50值为 2.1 nM。

产品描述

T-3775440 hydrochloride is an irreversible inhibitor of lysine-specific histone demethylase (LSD1)(IC50 : 2.1 nM).

体外活性

T-3775440, a novel irreversible LSD1 inhibitor.?Cell growth analysis of leukemia cell lines revealed that acute erythroid leukemia (AEL) and acute megakaryoblastic leukemia cells (AMKL) were highly sensitive to this compound.?T-3775440 treatment enforced transdifferentiation of erythroid/megakaryocytic lineages into granulomonocytic-like lineage cells.?Mechanistically, T-3775440 disrupted the interaction between LSD1 and growth factor-independent 1B (GFI1B), a transcription factor critical for the differentiation processes of erythroid and megakaryocytic lineage cells.?Knockdown of LSD1 and GFI1B recapitulated T-3775440-induced transdifferentiation and cell growth suppression, highlighting the significance of LSD1-GFI1B axis inhibition with regard to the anti-AML effects of T-3775440[1].

体内活性

T-3775440 exhibited significant antitumor efficacy in AEL and AMKL xenograft models[1].

Cas No.

1422535-52-1

分子式

C18H23ClN4O

分子量

346.85

储存和溶解度

DMSO:30.18 mg/mL (87.01 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years