GSK-LSD1 dihydrochloride 是一种特异性不可逆的 LSD1 抑制剂 (IC50: 16 nM)。GSK-LSD1 对 LSD1 的选择性是其他密切相关的 FAD 利用酶（即 MAO-A、LSD2、MAO-B）的 1000 倍以上。

GSK-LSD1 2HCl is a specificity irreversible LSD1 inhibitor (IC50: 16 nM). The selectivity of GSK-LSD1 for LSD1 is >1000 fold over other closely related FAD utilizing enzymes (i.e. MAO-A, LSD2, MAO-B).

GSK-LSD1 induces gene expression changes in cancer cell lines with average EC50 of< 5 nM and inhibits cancer cell line growth with average EC50 of< 5 nM. [1]

2102933-95-7

C14H22Cl2N2

289.24

GSK-LSD1 2HCl

DMSO:25 mg/mL (86.43 mM)
H2O:10 mg/mL (34.57 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years