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7-Methoxy-4-(trifluoromethyl)coumarin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
7-Methoxy-4-(trifluoromethyl)coumarin图片
CAS NO:575-04-2
包装与价格：
包装价格(元)
50mg电议
100mg电议
250mg电议

产品介绍
A fluorogenic substrate for CYPs
Cas No.575-04-2
别名7-甲氧基-4-(三氟甲基)香豆素
Canonical SMILESO=C1OC2=C(C(C(F)(F)F)=C1)C=CC(OC)=C2
分子式C11H7F3O3
分子量244.2
溶解度DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml,DMSO: 25 mg/ml,Ethanol: 10 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

7-Methoxy-4-(trifluoromethyl)coumarin is a fluorogenic substrate for cytochrome P450s (CYPs).1Upon enzymatic cleavage by CYPs, 7-hydroxy-4-(trifluoromethyl)coumarin (HFC) is released and its fluorescence can be used to quantify CYP activity. HFC displays excitation/emission maxima of 410/510 nm, respectively.

1.Donato, M.T., JimÉnez, N., Castell, J.V., et al.Fluorescence-based assays for screening nine cytochrome P450 (P450) activities in intact cells expressing individual human P450 enzymesDrug Metab. Dispos.32(7)699-706(2004)