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Gly3-VC-PAB-MMAE
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Gly3-VC-PAB-MMAE图片
CAS NO:2684216-48-4
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
Gly3-VC-PAB-MMAE 由可降解 (cleavable) 的 ADC linker (Gly3-VC-PAB) 和 MMAE 组成,MMAE 是一种有效的微管 (tubulin) 抑制剂。Gly3-VC-PAB-MMAE可用于合成抗体偶联药物 (ADC)。
Cas No.2684216-48-4
分子式C64H103N13O15
分子量1294.58
储存条件Store at -20°C,unstable in solution, ready to use.
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Gly3-VC-PAB-MMAE consists a cleavable ADC linker (Gly3-VC-PAB) and a potent tubulin inhibitor (MMAE). Gly3-VC-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs)[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.