Quercetagetin 是存在于万寿菊中的一种类黄酮，是一种选择性和细胞渗透性的Pim-1激酶抑制，IC50为 0.34 μM，具有抗炎和抗肿瘤活性。

Quercetagetin (6-Hydroxyquercetin) is the major flavonoid isolated from Citrus unshiu. It is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50: 0.34 μM).

Quercetagetin inhibits PIM2, PKA, and RSK2 (IC50s: 3.45, 21.2, and 2.82 μM). Quercetagetin (0.1, 1, 10, and 100 μM, 72 hours) inhibits growth of RWPE2 prostate cancer cells with average ED50 is 3.8 μM [2].

Quercetagetin significantly inhibits UVB-induced skin cancer development. Topical application of 4 or 20 nmol of Quercetagetin to mouse skin reduces tumor incidence by 32.0% and 46.7%, respectively [3].

Cell Line: RWPE2 prostate cancer cells. Concentration: 0.1, 1, 10, and 100 μM. Incubation Time: 72 hours [2]

Animal Model: SKH-1 hairless mice model. Dosage: 4 or 20 nmol. Administration: Topical application; 28 weeks [3]

90-18-6

C15H10O8

318.237

栎草亭;6-Hydroxyquercetin

DMSO:125 mg/mL (392.79 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years