EPZ020411是一种特异性有效的 PRMT6 抑制剂， IC50 为 10 nM，比作用于 PRMT1 和 PRMT8 的选择性高10倍多。

EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).

In PRMT6-overexpressing cells, EPZ020411 does-dependently inhibits H3R2 methylation.

in vivo: EPZ020411 shows good bioavailability following subcutaneous (SC) dosing in rats making it a suitable tool for in vivo studies.

1700663-41-7

C25H38N4O3

442.604

EPZ020411 2HCl

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years