Sinefungin是病毒粒子mRNA (鸟嘌呤-7-)-甲基转移酶、 mRNA (核苷-2'-)-甲基转移酶和病毒增殖的有效抑制剂。它还抑制SET7/9，通过抑制H3K4甲基化来改善肾纤维化。

Sinefungin is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. Sinefungin is a SET7/9 inhibitor and ameliorates renal fibrosis by inhibiting H3K4 methylation.

Sinefungin (0.5 or 1.0 μg/mL, 60 minutes) ameliorates the TGF-β1-induced increase of α-SMA. It also inhibits the upregulation of histone H3K4 monomethylation in renal epithelial cells and renal fibroblast cells [2].

In obstructive nephropathy, Sinefungin (10 mg/kg, per day immediately after UUO) improves renal fibrosis [2].

58944-73-3

C15H23N7O5

381.39

Antibiotic 32232RP;西奈芬净;Adenosyl-Ornithine;A-9145

H2O:95 mg/mL (249.09 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years