GSK2807 Trifluoroacetate 是一种选择性和 SAM 竞争性的 SMYD3 抑制剂，IC50为 130 nM，Ki值为 14 nM。

GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM).

GSK2807, a potent and selective, SAM-competitive inhibitor of SMYD3 (Ki = 14 nM).?A high-resolution crystal structure reveals that GSK2807 bridges the gap between the SAM-binding pocket and the substrate lysine tunnel of SMYD3. GSK2807 is 24-fold selective for SMYD3 in comparison with the closely related enzyme SMYD2 (Ki=14±6 nM and 345±36 nM, respectively) [1].

2245255-66-5

C21H33F3N8O7

566.53

H2O:50 mg/mL (88.26 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years