MOZ-IN-3 是一种MOZ,属于组蛋白乙酰转移酶的抑制剂,IC50值为 55 nM。
产品描述
MOZ-IN-3 is an inhibitor of MOZ(IC50=55 nM), a member of histone acetyltransferases.
体外活性
MOZ-IN-3is an inhibitor of MOZ(IC50=55 nM). MOZ-IN-3 causes cell senescence(IC50=1.6 μM) and suppresses the proliferation(IC50=551 nM).
激酶实验
Reactions are set up with Acetyl coenzyme A (AcCoA)(0.4 μM), N-terminal histone H4 peptide (sequence SGRGKGGKGLGKGGAKRHRKV-GGK-biotin)(50 nM), MOZ enzyme(10 nM), and an acetyl-lysine specific antibody (final dilution 1: 10000).
Cas No.
2055397-18-5
分子式
C20H17FN2O3S
分子量
384.43
别名
MOZ-IN-3
储存和溶解度
DMSO:250 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years