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NH2-PEG3-C1-Boc
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
NH2-PEG3-C1-Boc图片
CAS NO:189808-70-6
包装:100mg
市场价:1620元

产品介绍
NH2-PEG3-C1-Boc (PROTAC Linker 5) 是一种 PROTAC linker，属于 PEG 类。NH2-PEG3-C1-Boc 可用于合成 PROTAC 分子。
Cas No.189808-70-6
别名PROTAC Linker 5
Canonical SMILESNCCOCCOCCOCC(OC(C)(C)C)=O
分子式C12H25NO5
分子量263.33
溶解度DMSO : 100 mg/mL (379.75 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

NH2-PEG3-C1-Boc (PROTAC Linker 5) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References:
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.