CAS NO: | 2141981-88-4 |
包装: | 50mg |
市场价: | 8100元 |
Cas No. | 2141981-88-4 |
Canonical SMILES | O=C(OC1CC/C=C\CCC1)NCCOCCOCCOCCC(ON2C(CCC2=O)=O)=O |
分子式 | C22H34N2O9 |
分子量 | 470.51 |
溶解度 | DMSO: 100 mg/mL (212.54 mM) |
储存条件 | Store at -20℃ |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | TCO-PEG3-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. [1]. Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238. |