Gonadorelin Acetate (33515-09-2 free base) 是下丘脑神经肽，在控制生殖功能中起关键作用。

Gonadorelin Acetate is hypothalamic neuropeptide which plays a key role in the control of reproductive functions.

Luteinizing Hormone Releasing Hormone (LH-RH), also called gonadotropin-releasing hormone (GnRH), is the primary link between the brain, the pituitary and gonadal function, and has a key role in vertebrate reproduction. The endocrine actions of Luteinizing Hormone Releasing Hormone (LH-RH) and its analogs are mediated by high-affinity membrane receptors for LHRH on pituitary gonadotrophs. LHRH is expressed,together with its receptors,in hormonerelated tumors such as prostate cancer,to act as a local autocrine/paracrine growth inhibitory factor. In prostate cancer cells,the LHRH receptor is coupled to the Gi-cAMP pathway to inhibit cell proliferation.

Luteinizing Hormone Releasing Hormone treatment advances the timing of vaginal opening by 5 days, which is used as an initial indicator for the time of puberty.

Rat:Immature female Sprague-Dawley rats receive either 50 ng Luteinizing Hormone Releasing Hormone (LH-RH)/kg BW or 20 mg NMA/kg BW in a 10% dextrose, 0.9% NaCl solution, while controls receive only vehicle. After completion of the treatment, rats are examined daily for vaginal opening.

71447-49-9

C59H83N17O17

1302.415

Gonadorelin Acetate;Luteinizing Hormone Releasing Hormone (LH-RH);Luteinizing Hormone Releasing Hormone (LH-RH), human;醋酸戈那瑞林

H2O:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years