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Oxfendazole
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Oxfendazole图片
CAS NO:53716-50-0
包装与价格:
包装价格(元)
100 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
奥吩达唑
RS-8858
奥芬哒唑
产品介绍
Oxfendazole是fenbendazole的亚砜形式,是广谱苯并咪唑驱虫剂,可保护牲畜免受蛔虫、圆线虫和蛲虫的侵害。

产品描述

Oxfendazole, a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.

体内活性

Oxfendazole (OX) induces not only mRNA expression of phase I enzymes Cyp1a1, Cyp1a2, but also Nrf2-regulated phase II enzymes such as Gpx2, Nqo1, Yc2, Akr7a3 and Gstm1 in rats, presumably due to an adaptive response against OX-induced oxidative stress. Oxfendazole enhances oxidative DNA damage (as assessed by 8-hydroxydeoxyguanosine; 8-OHdG) and lipid peroxidation (as assessed by thiobarbituric acid-reactive substances; TBARS) in rats. [1] Oxfendazole administered at the therapeutic dose (4.5 mg/kg) and at the highest dose (22.5 mg/kg) increase 1.54- and 2.36-fold the total liver microsomal cytochrome P450 and more particularly the isoenzyme P450IA2 (95% and 184% increases) in rabbit liver. [2] Oxfendazole MRL induces a mutagenic effect in all tested cell types. Oxfendazole exhibits embryotoxicity including teratogenicity. Oxfendazole induces a disturbance in the different biochemical contents of all tested tissues in mice. [3] Oxfendazole increases the incidence and multiplicity of altered foci (4.0- and 3.6-fold, respectively) and hepatocellular adenomas (HCAs) (3.0- and 5.5-fold, respectively). Oxfendazole treatment induces 5.2- and 5.6-fold increases in the number of proliferating cell nuclear antigen (PCNA)-positive cells and single-stranded DNA (ssDNA)-positive cells in HCAs compared with the surrounding tissue, respectively. [4] Oxfendazole and its sulphone metabolite attain a significantly higher plasma concentration and remain much longer in plasma compared with fenbendazole (FBZ) and albendazole (ABZ) and their respective metabolites in dogs. [5]

Cas No.

53716-50-0

分子式

C15H13N3O3S

分子量

315.35

别名

奥吩达唑;RS-8858;奥芬哒唑

储存和溶解度

Ethanol:<1 mgml
H2O:<1 mgml
DMSO:10 mg/mL (31.71 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years