Genz-123346 free base 是一种能够阻断神经酰胺向GL1转化的GL1合酶的抑制剂,其抑制GM1的IC50值为14 nM。
产品描述
Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1.
体内活性
GLPG-1690 was able to cause a sustained reduction of LPA levels in plasma in vivo and was shown to be efficacious in a bleomycin-induced pulmonary fibrosis model in mice and in reducing extracellular matrix deposition in the lung while also reducing LPA 18:2 content in bronchoalveolar lavage fluid.
Cas No.
491833-30-8
分子式
C24H38N2O4
分子量
418.578
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years